Establishment and Development:
Kidney Multidisciplinary Innovation Lab was born from a shared vision and passion for renal pathophysiology and immune-inflammatory pathogenesis of kidney diseases. Recognizing the need for cutting edge academic research in CKD epidemiology, genetic background, renal pathophysiology, immune-inflammatory pathogenesis and evidence-based treatment of kidney diseases with international reputation, our founders decided to establish a laboratory dedicated to develop novel therapeutic strategies for kidney injury. The journey of Kidney Multidisciplinary Innovation Lab began with the department of nephrology in the Second Hospital of Shandong university that established in the 1990s by the founder Professor Guang-ju Guan. The nephrology department of the Second Hospital of Shandong University is the first key clinical specialty of the Ministry of Health in Shandong Province. With a dedicated team, we established Renal Institute of Shandong University in 2011. Under the leadership of Prof. Gang liu, the institute has been developing substantially. It has been crowned as Kidney Multidisciplinary Innovation Lab.
Team Members:
Our team has been keeping fast pace of stable and steady development; we have 21 nephrologists and physician-scientists, 13 master's graduate students and doctoral students. Among the nephrologists and physician-scientists, there are 3 full professors and 7 associated professors. Four have been awarded grants form Natural Science Foundation of China (NSFC)；2 has been awarded grants form the Science Foundation of Shandong province; 3 have been ranked as new talents pioneers of the Second Hospital of Shandong University. Our renal program has been recognized as a young, passionate and dynamic one.
Research Areas:
Based on multidisciplinary technological platform and the database of clinical kidney biopsy , our lab has been focusing on three main directions of scientific research:
To investigate the pathogenesis of common kidney diseases of CKD
To identify the risk factors, immune-inflammatory mechanism and genetic background in developing and progression of diabetic kidney disease(DKD);
To develop prevention and stem cell treatment strategies of CKD.
Research Achievements:
We have made significant contributions in elucidating the potential immune-inflammatory mechanism of mesenchymal stem cells ameliorate diabetic glomerular fibrosis, the cellular and molecular mechanism in preventing diabetic kidney disease and investigate the pathogenesis of common kidney diseases of CKD.
Main Publications:
[1] Wang Y, Liu J, Wang H, Lv S, Liu Q, Li S, Yang X, Liu G*. Mesenchymal stem cell-derived exosomes ameliorate diabetic kidney disease through the NLRP3 signaling pathway. Stem Cells. 2023 Jan 22:sxad010. doi: 10.1093/stmcls/sxad010. Epub ahead of print. PMID: 36682034.
[2] Wang Y, Liu J, Zhang Q, Wang W, Liu Q, Liu S, Song Y, Wang X, Zhang Y, Li S, Yang X, Lv S, Liu G*. Human umbilical cord mesenchymal stem cells attenuate podocyte injury under high glucose via TLR2 and TLR4 signaling. Diabetes Res Clin Pract. 2021 Mar;173:108702. doi: 10.1016/j.diabres.2021.108702. Epub 2021 Feb 18. PMID: 33609619.
[3] Song Y, Lv S, Wang F, Liu X, Cheng J, Liu S, Wang X, Chen W, Guan G, Liu G*, Peng C*. Overexpression of BMP 7 reverses TGF β1 induced epithelial mesenchymal transition by attenuating the Wnt3/β catenin and TGF-β1/Smad2/3 signaling pathways in HK 2 cells. Mol Med Rep. 2020 Feb;21(2):833-841. doi: 10.3892/mmr.2019.10875. Epub 2019 Dec 10. PMID: 31974602; PMCID: PMC6947920.
[4] Song Y, Peng C, Lv S, Cheng J, Liu S, Wen Q, Guan G, Liu G*. Adipose-derived stem cells ameliorate renal interstitial fibrosis through inhibition of EMT and inflammatory response via TGF-β1 signaling pathway. Int Immunopharmacol. 2017 Mar;44:115-122. doi: 10.1016/j.intimp.2017.01.008. Epub 2017 Jan 13. PMID: 28092863.
[5] Wang XL, Wu LY, Zhao L, Sun LN, Liu HY, Liu G*, Guan GJ*. SIRT1 activator ameliorates the renal tubular injury induced by hyperglycemia in vivo and in vitro via inhibiting apoptosis. Biomed Pharmacother. 2016 Oct;83:41-50. doi: 10.1016/j.biopha.2016.06.009. Epub 2016 Jun 21. PMID: 27470548.
Facilities & Resources:
The laboratory is based on the Institute of Kidney Disease of Shandong University and the Second Hospital of Shandong University. The laboratory has 4 experimental platforms: molecular biology experimental platform, cell biology experimental platform, immunology and histopathology experimental platform, protein electrophoresis platform, 1 biological sample bank, 6 public laboratories: Microscope room, flow cytometry room, precision instrument room, purification laboratory, virus room, centrifuge room. With automatic enzyme marker, fluorescent real-time quantitative PCR Instrument, microfluorescence imaging system, confocal microscope, digital microtome scanner, automatic dewatering machine, tissue encapsulation machine, pathological microtome, frozen microtome, high-speed and low temperature centrifuge, ultra-fast centrifuge, magnetic stirrer, protein electrophoresis tank, electrophoresis machine, cell constant temperature incubator, ultra-clean table, tissue shredder and various refrigerators can meet the various instruments and equipment required for the completion of the project . With the support of School of Pharmacy, Shandong University and Department of Pathology, Shandong University, this project can complete important experiments such as quantitative analysis of tissue metabolites by liquid chromatography tandem mass spectrometry (LC-MS/MS), whole genome DNA methylation sequencing and electron microscope examination. The working conditions required for the experimental topics are fully met. We also have our database of clinical kidney biopsy for reaserchers.
Collaborations & Partnerships:
We believe in the power of collaboration. We established the Kidney Multidisciplinary Innovation Branch of Shandong Medical Association in 2021, which include the disciplines of renal internal medicine, blood purification, peritoneal dialysis, kidney transplantation, kidney pathology, pediatric nephrology, and basic renal medicine of major medical and teaching/research institutions in Shandong Province.
Contact:
For more information or inquiries, please contact us
PI of Kidney Multidisciplinary Innovation Lab
Email address: lg-2000@163.com
Telephone: (+86)17660086617
Address: 247 Beiyuan Street, Jinan City, Shandong Province
Website: http://www.sdey.net
