Establishment and Development:

Endocrinology and Metabolism Lab of the Second Hospital of Shandong University was born from a shared vision and passion for diabetic neuropathy. Recognizing the need to understand the mechanisms and therapeutic targets of diabetic neuropathy, our founders decided to establish a laboratory dedicated to explore the mechanisms of Lipin1 in diabetic neuropathy. We set out to establish a research laboratory that would stand out for its excellence and impact. We have published a number of articles and won some honors in recent years. Since its inception, Endocrinology Research Group of the Second Hospital of Shandong University has gone through a remarkable journey of growth and development. Our study direction has been developed into investigating the pathogenesis, diagnostic markers and therapeutic targets of diabetic peripheral neuropathy, diabetic encephalopathy and depression with diabetes. Additionally, we have established valuable collaborations and partnerships with the Department of Physiology, the Department of Anatomy and Neurobiology, the Department of Biostatistics, and the School of Control Science and Data of Shandong University to further enhance our research capabilities.

Team Members:

Our lab is located in the Second Hospital of Shandong University, Shandong, China. We are broadly interested in a wide range of topics related to endocrinology and metabolism, neuroscience, epidemiology, informatics and biomedical engineering. Our team is composed of 3 professors, 2 postdoctors, 6 doctors and 12 masters. Professor Shihong Chen and Professor Xianghua Zhuang have been engaged in the clinical and basic research of diabetic peripheral neuropathy and diabetic encephalopathy for a long time, and have accumulated lots of experience in clinical treatment and pathogenesis research. Professor Shuyan Yu is committed to the study of the nervous system, using viral tracing, genetic engineering, pharmacology, electrophysiology and behavioral methods to explore the pathogenesis and experimental treatment of psychiatric diseases.

Our lab has abundant scientific research experience, mighty innovation ability, it is a solidarity and passionate team. Team members have clear tasks and responsibilities. Our team has established a form of team cooperation with complementary advantages and formed a good team atmosphere.

Research Areas:

Endocrinology and Metabolism Lab specializes in diabetic peripheral neuropathy and diabetic encephalopathy. Our lab explores the pathogenesis, early diagnostic markers, clinical translation of therapeutic drugs and functional imaging of neurological complications of diabetes mellitus.

Research Achievements:

Endocrinology and Metabolism Lab explored the mechanism of diabetic peripheral neuropathy and diabetic encephalopathy from different perspectives such as phospholipid metabolism, inflammatory response, mitochondrial function, adult hippocampal neurogenesis and so on. Focusing on clinical needs, we also found different markers and established diagnostic system for early monitoring and treatment of diabetic neuropathy. We have made significant contributions in Nature communications, Redox Biology, Journal of Neuroinflammation, International Immunopharmacology et al. Three professors in our lab have hosted 10 National Natural Science Foundation projects and a number of provincial projects. The research achievements of our group won the second prize of Shandong Province Science and Technology Progress Award.

Main Publications:

[1] Yinliang Zhang; Chunyuan Du; Wei Wang; Wei Qiao; Yuhui Li; Yujie Zhang; Sufang Sheng;Xuenan Zhou; Lei Zhang; Heng Fan; Ying Yu; Yong Chen; Yunfei Liao; Shihong Chen; Yongsheng Chang; Glucocorticoids increase adiposity by stimulating Krüppel-like factor 9 expression in macrophages, Nature communications, 2024, 15(1): 1190.

[2] Xiaolin Han; Shan Huang; Ziyun Zhuang; Xiaochen Zhang; Min Xie; Nengjun Lou; Mengyu Hua;Xianghua Zhuang; Shuyan Yu; Shihong Chen ; Phosphatidate phosphatase Lipin1 involves in diabetic encephalopathy pathogenesis via regulating synaptic mitochondrial dynamics, Redox Biology, 2024,69(102996).

[3] Changmin Wang; Ye Li; Yuhang Yi; Guiyu Liu; Ruojing Guo; Liyan Wang; Tian Lan; Wenjing Wang; Xiao Chen; Shihong Chen; Shu Yan Yu ; Hippocampal microRNA-26a-3p deficit contributes to neuroinflammation and behavioral disorders via p38 MAPK signaling pathway in rats, Journal of Neuroinflammation, 2022, 19(1): 283.

[4] Tian Lan; Ye Li; Cuiqin Fan; Liyan Wang; Wenjing Wang; Shihong Chen; Shu Yan Yu ;MicroRNA-204-5p reduction in rat hippocampus contributes to stress-induced pathology viatargeting RGS12 signaling pathway, Journal of Neuroinflammation, 2021, 18(1): 243.

[5] Xiaochen Zhang; Shan Huang; Ziyun Zhuang; Xiaolin Han; Min Xie; Shuyan Yu; Mengyu Hua; Zhonghao Liang; Chao Meng; Ling Yin; Xianghua Zhuang; Shihong Chen ; Lipin2 ameliorates diabetic encephalopathy via suppressing JNK/ERK-mediated NLRP3 inflammasome overactivation, InternationalImmunopharmacology, 2023, 118: 109930.

[6] Wang Wenjing., Wang Lihong., Wang Liyan., Li Ye., Lan Tian., Wang Changmin., Chen Xiao., Chen Shihong., Yu Shuyan.(2023). Ginsenoside-Rg1 synergized with voluntary running exercise protects against glial activation and dysregulation of neuronal plasticity in depression. Food Funct, 14(15), 7222-7239.

[7] Wang Meijian., Xie Min., Yu Shuyan., Shang Pan., Zhang Cong., Han Xiaolin., Fan Cuiqin., Chen Li., Zhuang Xianghua., Chen Shihong.(2021). Lipin1 Alleviates Autophagy Disorder in Sciatic Nerve and Improves Diabetic Peripheral Neuropathy. Mol Neurobiol, 58(11), 6049-6061.

[8] Wang Meijian., Hou Xinguo., Hu Wenchao., Chen Li., Chen Shihong.(2019). Serum lipid and lipoprotein levels of middle-aged and elderly Chinese men and women in Shandong Province. Lipids Health Dis, 18(1), 58.

[9] Zheng Guanlin., Li Haizhen., Zhang Tie., Yang Libo., Yao Shutong., Chen Shihong., Zheng Maochuan., Zhao Qin., Tian Hua.(2018). Irisin protects macrophages from oxidized low density lipoprotein-induced apoptosis by inhibiting the endoplasmic reticulum stress pathway. Saudi J Biol Sci, 25(5), 849-857.

[10] Shang Pan., Zheng Fengjie., Han Feng., Song Yuwen., Pan Zhe., Yu Shuyan., Zhuang Xianghua., Chen Shihong.(2020). Lipin1 mediates cognitive impairment in fld mice via PKD-ERK pathway. Biochem Biophys Res Commun, 525(2), 286-291.

10 selected publications

Facilities & Resources:

The clinical research is based on the platform of Shandong Provincial priority clinical specialty and National Standardized Metabolic Disease Management Center. The basic research is based on the Basic Research Institute of the Second Hospital of Shandong University, the Key Laboratory of Basic and Clinical Mental Diseases of Shandong Province, and the Key Laboratory of Translational Medicine of Neurodegenerative Diseases in universities of Shandong Province.

Our state-of-the-art facilities and cutting-edge technology enable us to conduct research that is both rigorous and innovative. We boast Metabolic cage, behavioral tests, Transmission electron microscopy, inverted confocal microscope, et al.

Collaborations & Partnerships:

We believe in the power of collaboration. That's why we have forged partnerships with Tianjin Medical University, Qilu Hospital of Shandong University, the Department of Physiology, the Department of Anatomy and Neurobiology, the Department of Biostatistics, and the School of Control Science and Data of Shandong University to further advance our research.

Recreational Activities:

Our team is a solidarity and relaxed group, and there is a friend-like relationship between professors and students. We often dine together, and also hold a party during the Spring Festival. We often organize some recreational activities, such as climbing mountains with team members, running, and Murder Mystery Game and Escape Rooms.

Other Features:

Our lab group is growing rapidly and we welcome all forms of communication and cooperation. All you can see is the road under your feet, and you already have the distant oasis in your mind.

Contact:

chenshihong26@163.com